Article
G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus.
Circulation - 15 Jun 2004
März Winfried, Nauck Markus, Hoffmann Michael M, Nagel Dietmar, Boehm Bernhard O, Koenig Wolfgang, Rothenbacher Dietrich, Winkelmann Bernhard R
Abstract excerpt
BACKGROUND: Type 2 diabetes mellitus (T2DM) increases the risk of coronary artery disease (CAD). A G(-30)A polymorphism in the beta-cell-specific promoter of glucokinase (GK-30PM) has been implicated in reduced pancreatic beta-cell function. Its impact on CAD has not been examined. METHODS AND RESULTS: The glucokinase G(-30)A variant was determined in 2567 patients with angiographic CAD and in 731 individuals in...
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