Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.

Oncogene - 24 Jun 2004

Kimmelman Alec C, Qiao Rui F, Narla Goutham, Banno Asoka, Lau Nelson, Bos Paula D, Nuñez Rodriguez Nelson, Liang Bertrand C, Guha Abhijit, Martignetti John A, Friedman Scott L, Chan Andrew M

Abstract excerpt

The Kruppel-like transcription factor KLF6 is a novel tumor-suppressor gene mutated in a significant fraction of human prostate cancer. It is localized to human chromosome 10p14-15, a region that displays frequent loss of heterozygosity in glioblastoma multiforme (GBM). Indeed, mutations of the K...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Brain Neoplasms
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Glioblastoma

Share to Kruppel-Like Transcription Factors

Share to Mice, Nude

Share to Neoplasm Transplantation

Source

Identifiers

PMID: 15064720
DOI: 10.1038/sj.onc.1207662

Genes

KLF6
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15064720-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.PMID 15064720Read ↗

KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas.Semantic proximity Read ↗

Inactivation of the tumor suppressor Krüppel-like factor 6 (KLF6) by mutation or decreased expression in hepatocellular carcinomas.Semantic proximity Read ↗

KLF6, a candidate tumor suppressor gene mutated in prostate cancer.Semantic proximity Read ↗

Deletion, mutation, and loss of expression of KLF6 in human prostate cancer.Semantic proximity Read ↗

Krüppel-like factors in tumors: Key regulators and therapeutic avenuesSemantic proximity Read ↗

RBPJ contributes to the malignancy of glioblastoma and induction of proneural‐mesenchymal transition via IL‐6‐STAT3 pathwaySemantic proximity Read ↗

SLFN11 Negatively Regulates Noncanonical NFκB Signaling to Promote Glioblastoma ProgressionSemantic proximity Read ↗

Expression and Function of Kruppel Like-Factors (KLF) in CarcinogenesisSemantic proximity Read ↗

Suppression of putative tumour suppressor gene GLTSCR2 expression in human glioblastomas.Semantic proximity Read ↗

<i>GATA6</i> is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma modelSemantic proximity Read ↗

LY6K promotes glioblastoma tumorigenicity via CAV-1–mediated ERK1/2 signaling enhancementSemantic proximity Read ↗

Characterization of the prostate cancer susceptibility gene KLF6 in human and mouse prostate cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.