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Article

Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma.

Hepatology (Baltimore, Md.) - 1 Nov 2004

Kremer-Tal Sigal, Reeves Helen L, Narla Goutham, Thung Swan N, Schwartz Myron, Difeo Analisa, Katz Amanda, Bruix Jordi, Bioulac-Sage Paulette, Martignetti John A, Friedman Scott L

Abstract excerpt

Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, reflecting incomplete characterization of underlying mechanisms and lack of early detection. Kruppel-like factor 6 (KLF6) is a ubiquitously expressed zinc finger transcription factor that is deregulated in multiple cancers through loss of heterozygosity (LOH) and/or inactivating somatic mutation. We analyzed the potential role of the...

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Identifiers

PMID: 15486921
DOI: 10.1002/hep.20460

Genes

KLF6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma.PMID 15486921Read ↗

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