Article
p53 is an independent pre-treatment markers for long-term survival in stage II and III colorectal cancers: an analysis of interaction between genetic markers and fluorouracil-based adjuvant therapy.
Cancer letters - 8 Jul 2004
Tang Reiping, Wang Jeng-Yi, Fan Chung-Wei, Tsao Kuo-Chien, Chen Hong-Hua, Wu Chi-Ming, Chen Jinn-Shiun, Changchien Chung Rong, Hsieh Ling-Ling
Abstract excerpt
One hundred and thirty-eight stage II and III colorectal cancer patients were included to evaluate the prognostic significance of genetic markers (including mutations of the p53, K-ras genes, and microsatellite instability) on the response to 5-fluorouracil (FU)-based post-operative adjuvant therapies (PAT). When stratified by PAT and adjusting for other prognostic variables, presence of p53 mutation was...
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