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Article

Sry-directed sex reversal in transgenic mice is robust with respect to enhanced DNA bending: comparison of human and murine HMG boxes.

Biochemistry - 8 Jun 2004

Phillips Nelson B, Nikolskaya Tatiana, Jancso-Radek Agnes, Ittah Varda, Jiang Fashun, Singh Rupinder, Haas Elisha, Weiss Michael A

Abstract excerpt

The testis-determining factor SRY contains an HMG box DNA-bending domain. Human and murine factors (hSRY and mSRY, respectively) exhibit marked sequence divergence and are reported to differ markedly in DNA bending properties. Surprisingly, the combined application of time-resolved fluorescence resonance energy transfer (tr-FRET) and permutation gel electrophoresis demonstrates that the hSRY-DNA complex is more...

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Share to Circular Dichroism
Share to Disorders of Sex Development

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to High Mobility Group Proteins

Share to Magnetic Resonance Spectroscopy

Share to Mutagenesis, Site-Directed

Share to Sequence Homology, Amino Acid

Share to Sex-Determining Region Y Protein

Share to Spectrometry, Fluorescence

Source

Identifiers

PMID: 15170344
DOI: 10.1021/bi049920a

Genes

SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sry-directed sex reversal in transgenic mice is robust with respect to enhanced DNA bending: comparison of human and murine HMG boxes.PMID 15170344Read ↗

SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending.Semantic proximity Read ↗

An SRY mutation causing human sex reversal resolves a general mechanism of structure-specific DNA recognition: application to the four-way DNA junction.Semantic proximity Read ↗

Generation and mutational analysis of a transgenic mouse model of human SRYSemantic proximity Read ↗

SRYand architectural gene regulation: the kinetic stability of a bent protein-DNA complex can regulate its transcriptional potency.Semantic proximity Read ↗

SRY-directed DNA bending and human sex reversal: reassessment of a clinical mutation uncovers a global coupling between the HMG box and its tail.Semantic proximity Read ↗

Structure-function relationships in human testis-determining factor SRY: an aromatic buttress underlies the specific DNA-bending surface of a high mobility group (HMG) box.Semantic proximity Read ↗

Structure–function analysis of mouse Sry reveals dual essential roles of the C-terminal polyglutamine tract in sex determinationSemantic proximity Read ↗

Interaction of normal and mutant SRY proteins with DNA.Semantic proximity Read ↗

Sry is a transcriptional activator.Semantic proximity Read ↗

Molecular basis of mammalian sexual determination: activation of Mullerian inhibiting substance gene expression by SRYSemantic proximity Read ↗

Sex-reversing mutations affect the architecture of SRY-DNA complexes.Semantic proximity Read ↗

The mouse <i>Sry</i> locus harbors a cryptic exon that is essential for male sex determinationSemantic proximity Read ↗

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