Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction of normal and mutant SRY proteins with DNA.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Nov 1995

Rimini R, Pontiggia A, Spada F, Ferrari S, Harley V R, Goodfellow P N, Bianchi M E

Abstract excerpt

In mammals, sex determination is caused by the Y-chromosome gene SRY. The DNA-binding domain of human SRY protein is similar to those of the chromatin protein HMG1. Like HMG1, SRY binds to kinked DNA structures, and bends linear DNA sharply upon binding. We analysed the biochemical properties of mutant SRY proteins from five patients with complete gonadal dysgenesis: two bind and bend DNA almost normally, two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression

Share to Mutation

Share to Nuclear Proteins

Share to Nucleic Acid Conformation

Share to Transcription Factors

Source

Identifiers

PMID: 8570684
DOI: 10.1098/rstb.1995.0154

Genes

SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of normal and mutant SRY proteins with DNA.PMID 8570684Read ↗

Sex-reversing mutations affect the architecture of SRY-DNA complexes.Semantic proximity Read ↗

SRY-directed DNA bending and human sex reversal: reassessment of a clinical mutation uncovers a global coupling between the HMG box and its tail.Semantic proximity Read ↗

Molecular basis of mammalian sexual determination: activation of Mullerian inhibiting substance gene expression by SRYSemantic proximity Read ↗

SRY protein function in sex determination: thinking outside the box.Semantic proximity Read ↗

SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending.Semantic proximity Read ↗

Structure-function relationships in human testis-determining factor SRY: an aromatic buttress underlies the specific DNA-bending surface of a high mobility group (HMG) box.Semantic proximity Read ↗

The role of SRY in mammalian sex determination.Semantic proximity Read ↗

Structure–function analysis of mouse Sry reveals dual essential roles of the C-terminal polyglutamine tract in sex determinationSemantic proximity Read ↗

The novel p.E89K mutation in the SRY gene inhibits DNA binding and causes the 46,XY disorder of sex development.Semantic proximity Read ↗

Familial mutation in the testis-determining gene SRY shared by an XY female and her normal father.Semantic proximity Read ↗

An SRY mutation causing human sex reversal resolves a general mechanism of structure-specific DNA recognition: application to the four-way DNA junction.Semantic proximity Read ↗

The Molecular Action and Regulation of the Testis-Determining Factors, SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High-Mobility Group (HMG) Box 9]Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.