Article
SRYand architectural gene regulation: the kinetic stability of a bent protein-DNA complex can regulate its transcriptional potency.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2001
Ukiyama E, Jancso-Radek A, Li B, Milos L, Zhang W, Phillips N B, Morikawa N, King C Y, Chan G, Haqq C M, Radek J T, Poulat F, Donahoe P K, Weiss M A
Abstract excerpt
Protein-directed DNA bending is proposed to regulate assembly of higher-order DNA-multiprotein complexes (enhanceosomes and repressosomes). Because transcriptional initiation is a nonequilibrium process, gene expression may be modulated by the lifetime of such complexes. The human testis-determining factor SRY contains a specific DNA-bending motif, the high-mobility group (HMG) box, and is thus proposed to...
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