An SRY mutation causing human sex reversal resolves a general mechanism of structure-specific DNA recognition: application to the four-way DNA junction.

doi:10.1021/bi00014a009

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

An SRY mutation causing human sex reversal resolves a general mechanism of structure-specific DNA recognition: application to the four-way DNA junction.

Biochemistry - 11 Apr 1995

Peters R, King C Y, Ukiyama E, Falsafi S, Donahoe P K, Weiss M A

Abstract excerpt

SRY, a genetic "master switch" for male development in mammals, exhibits two biochemical activities: sequence-specific recognition of duplex DNA and sequence-independent binding to the sharp angles of four-way DNA junctions. Here, we distinguish between these activities by analysis of a mutant SR...

Topics

Amino Acid Sequence
Base Sequence
DNA
DNA-Binding Proteins
Disorders of Sex Development
Female
Humans
Isoleucine
Male
Models, Molecular
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Nucleic Acid Conformation

Sequence Alignment

Sex Differentiation

Sex-Determining Region Y Protein

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 7718558
DOI: 10.1021/bi00014a009

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7718558-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An SRY mutation causing human sex reversal resolves a general mechanism of structure-specific DNA recognition: application to the four-way DNA junction.PMID 7718558Read ↗

Sry-directed sex reversal in transgenic mice is robust with respect to enhanced DNA bending: comparison of human and murine HMG boxes.Semantic proximity Read ↗

SRY-directed DNA bending and human sex reversal: reassessment of a clinical mutation uncovers a global coupling between the HMG box and its tail.Semantic proximity Read ↗

Structure-function relationships in human testis-determining factor SRY: an aromatic buttress underlies the specific DNA-bending surface of a high mobility group (HMG) box.Semantic proximity Read ↗

Interaction of normal and mutant SRY proteins with DNA.Semantic proximity Read ↗

Inherited Human Sex Reversal due to Loss of a Water-Mediated Hydrogen Bond at a Conserved Protein-DNA InterfaceSemantic proximity Read ↗

SRYand architectural gene regulation: the kinetic stability of a bent protein-DNA complex can regulate its transcriptional potency.Semantic proximity Read ↗

SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending.Semantic proximity Read ↗

Sex-reversing mutations affect the architecture of SRY-DNA complexes.Semantic proximity Read ↗

Generation and mutational analysis of a transgenic mouse model of human SRYSemantic proximity Read ↗

Novel mutations affecting SRY DNA-binding activity: the HMG box N65H associated with 46,XY pure gonadal dysgenesis and the familial non-HMG box R30I associated with variable phenotypes.Semantic proximity Read ↗

The novel p.E89K mutation in the SRY gene inhibits DNA binding and causes the 46,XY disorder of sex development.Semantic proximity Read ↗

Molecular basis of mammalian sexual determination: activation of Mullerian inhibiting substance gene expression by SRYSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.