Article
Molecular basis of mammalian sexual determination: activation of Mullerian inhibiting substance gene expression by SRY
2 Dec 1994
Abstract excerpt
The pathway of male sexual development in mammals is initiated by SRY, a gene on the short arm of the Y chromosome. Its expression in the differentiating gonadal ridge directs testicular morphogenesis, characterized by elaboration of Müllerian inhibiting substance (MIS) and testosterone. SRY and MIS each belong to conserved gene families that function in the control of growth and differentiation. Structural and...