Article
Effect of Humanizing Mutations on the Stability of the Llama Single-Domain Variable Region.
Biomolecules - 26 Jan 2021
Soler Miguel A, Medagli Barbara, Wang Jiewen, Oloketuyi Sandra, Bajc Gregor, Huang He, Fortuna Sara, de Marco Ario
Abstract excerpt
In vivo clinical applications of nanobodies (VHHs) require molecules that induce minimal immunoresponse and therefore possess sequences as similar as possible to the human VH domain. Although the relative sequence variability in llama nanobodies has been used to identify scaffolds with partially humanized signature, the transformation of the Camelidae hallmarks in the framework2 still represents a major problem....
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