Article
Investigation of the cyclobutane pyrimidine dimer (CPD) photolyase DNA recognition mechanism by NMR analyses.
The Journal of biological chemistry - 30 Jul 2004
Torizawa Takuya, Ueda Takumi, Kuramitsu Seiki, Hitomi Kenichi, Todo Takeshi, Iwai Shigenori, Morikawa Kosuke, Shimada Ichio
Abstract excerpt
The cyclobutane pyrimidine dimer (CPD) is one of the major forms of DNA damage caused by irradiation with ultraviolet (UV) light. CPD photolyases recognize and repair UV-damaged DNA. The DNA recognition mechanism of the CPD photolyase has remained obscure because of a lack of structural information about DNA-CPD photolyase complexes. In order to elucidate the CPD photolyase DNA binding mode, we performed NMR...
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