Article
The mechanism of action of DNA photolyases.
Current opinion in chemical biology - 1 Oct 2001
Carell T, Burgdorf L T, Kundu L M, Cichon M
Abstract excerpt
Structural analysis, biochemistry and model studies have provided new insights into the mechanism of action of photolyases. The light-driven electron and energy transfer events that lead to the photolyase-catalyzed repair of lethal, mutagenic and carcinogenic UV-light-induced DNA lesions have all been examined in the past few years.
Topics
- Carcinogens
- Catalysis
- DNA
- DNA Damage
- DNA Repair
- Deoxyribodipyrimidine Photo-Lyase
- Humans
- Light
- Molecular Structure
- Mutation
- Oxidation-Reduction
- Pyrimidine Dimers
- Substrate Specificity