Article
Mother-to-child transmission of HIV-1: strong association with certain maternal HLA-B alleles independent of viral load implicates innate immune mechanisms.
Journal of acquired immune deficiency syndromes (1999) - 1 Jun 2004
Winchester Robert, Pitt Jane, Charurat Manhattan, Magder Laurence S, Göring Harald H H, Landay Alan, Read Jennifer S, Shearer William, Handelsman Edward, Luzuriaga Katherine, Hillyer George V, Blattner William
Abstract excerpt
The transmission of HIV-1 from mother to child during pregnancy is unlike other types of HIV-1 transmission because the child shares major histocompatibility complex (MHC) genes with the mother during a time while the mother is induced to tolerate the paternally derived fetal MHC molecules, in part through natural killer (NK) recognition of MHC polymorphisms. The relevance of these immune mechanisms to HIV-1...
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