A Family with Severe Insulin Resistance and Diabetes Due to a Mutation in <i>AKT2</i>

Abstract excerpt

Inherited defects in signaling pathways downstream of the insulin receptor have long been suggested to contribute to human type 2 diabetes mellitus. Here we describe a mutation in the gene encoding the protein kinase AKT2/PKBbeta in a family that shows autosomal dominant inheritance of severe insulin resistance and diabetes mellitus. Expression of the mutant kinase in cultured cells disrupted insulin signaling to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neurogenetic and Muscular Disorders Research
• Share to Pancreatic function and diabetes
• Share to PI3K/AKT/mTOR signaling in cancer