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Article

Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase.

The Journal of biological chemistry - 30 Jul 2004

Wallace Matthew Alan, Liou Lee-Loung, Martins Jacob, Clement Matthew H S, Bailey Sasaneh, Longo Valter D, Valentine Joan Selverstone, Gralla Edith Butler

Abstract excerpt

Among the phenotypes of Saccharomyces cerevisiae mutants lacking CuZn-superoxide dismutase (Sod1p) is an aerobic lysine auxotrophy; in the current work we show an additional leaky auxotrophy for leucine. The lysine and leucine biosynthetic pathways each contain a 4Fe-4S cluster enzyme homologous to aconitase and likely to be superoxide-sensitive, homoaconitase (Lys4p) and isopropylmalate dehydratase (Leu1p),...

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PMID: 15166213
DOI: 10.1074/jbc.M403590200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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