Article
Yeast lacking superoxide dismutase. Isolation of genetic suppressors.
The Journal of biological chemistry - 15 Sept 1992
Liu X F, Elashvili I, Gralla E B, Valentine J S, Lapinskas P, Culotta V C
Abstract excerpt
Null mutants of superoxide dismutase (SOD) in Saccharomyces cerevisiae are associated with a number of biochemical defects. In addition to being hypersensitive to oxygen toxicity, strains containing deletions in both the SOD1 (encoding Cu/Zn-SOD) and SOD2 (encoding Mn-SOD) genes are defective in sporulation, are associated with a high mutation rate, and are unable to biosynthesize lysine and methionine. The...
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