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Article

Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin.

Genetics - 1 May 2004

Lesage Guillaume, Sdicu Anne-Marie, Ménard Patrice, Shapiro Jesse, Hussein Shamiza, Bussey Howard

Abstract excerpt

Large-scale screening of genetic and chemical-genetic interactions was used to examine the assembly and regulation of beta-1,3-glucan in Saccharomyces cerevisiae. Using the set of deletion mutants in approximately 4600 nonessential genes, we scored synthetic interactions with genes encoding subunits of the beta-1,3-glucan synthase (FKS1, FKS2), the glucan synthesis regulator (SMI1/KNR4), and a...

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Source

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Identifiers

PMID: 15166135
DOI: 10.1534/genetics.167.1.35
PMCID: PMC1470839

Genes

GAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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