Article
Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation.
PLoS pathogens - 1 Feb 2007
Kramer Roger W, Slagowski Naomi L, Eze Ngozi A, Giddings Kara S, Morrison Monica F, Siggers Keri A, Starnbach Michael N, Lesser Cammie F
Abstract excerpt
Numerous bacterial pathogens manipulate host cell processes to promote infection and ultimately cause disease through the action of proteins that they directly inject into host cells. Identification of the targets and molecular mechanisms of action used by these bacterial effector proteins is critical to understanding pathogenesis. We have developed a systems biological approach using the yeast Saccharomyces...
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