Article
Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study.
Diabetes - 1 Jun 2004
Lakka Timo A, Rankinen Tuomo, Weisnagel S John, Chagnon Yvon C, Lakka Hanna-Maaria, Ukkola Olavi, Boulé Normand, Rice Treva, Leon Arthur S, Skinner James S, Wilmore Jack H, Rao D C, Bergman Richard, Bouchard Claude
Abstract excerpt
We recently reported that a genomic region close to the leptin locus was linked to fasting insulin response to exercise training in nondiabetic white subjects. We tested the hypothesis that common exonic variants in the leptin (LEP) and leptin receptor (LEPR) genes modify the effects of regular physical activity on glucose homeostasis in nondiabetic whites (n = 397) and blacks (n = 143). In whites, exercise...
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