Article
Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance.
The Journal of clinical endocrinology and metabolism - 1 Jul 2001
Wauters M, Mertens I, Rankinen T, Chagnon M, Bouchard C, Van Gaal L
Abstract excerpt
Leptin receptors are present on beta-cells as well as on muscle and fat cells, thus enabling leptin to modulate both insulin secretion and insulin action. Leptin inhibits especially the glucose-stimulated insulin secretion from pancreatic cells. The leptin receptor (LEPR) gene could thus play a role in the regulation of glucose and insulin after an oral glucose load. Therefore, the relationship between LEPR...
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