Article
Common SNPs in LEP and LEPR associated with birth weight and type 2 diabetes-related metabolic risk factors in twins.
International journal of obesity (2005) - 1 Aug 2008
Souren N Y, Paulussen A D, Steyls A, Loos R J, Stassen A P, Gielen M, Smeets H J, Beunen G, Fagard R, Derom C, Vlietinck R, Geraedts J P, Zeegers M P
Abstract excerpt
OBJECTIVE: Children born small for gestational age are at increased risk of developing type 2 diabetes in adulthood. The satiety signal leptin that regulates food intake and energy expenditure might be a possible molecular link, as umbilical cord leptin levels are positively correlated with birth weight. In the present study, we examined whether common single nucleotide polymorphisms (SNPs) in the leptin (LEP;...
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