Article
Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and with the risk of myocardial infarction and of type 2 diabetes mellitus.
Endokrynologia Polska - 1 Jan 2014
Roszkowska-Gancarz Małgorzata, Kurylowicz Alina, Polosak Jacek, Mossakowska Małgorzata, Franek Edward, Puzianowska-Kuźnicka Monika
Abstract excerpt
INTRODUCTION: Longevity is commonly associated with good health and with delayed onset of age-related diseases with usually benign course. Leptin (LEP) significantly affects metabolism and numerous functions of the organism. To find out if extreme longevity and its phenotype are associated with genetic variants of leptin and leptin receptor (LEPR) genes, we analysed the frequencies of the -2548 G/A and +19 G/A...
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