Gene therapy of cancer through restoration of tumor-suppressor functions?

doi:10.1002/1097-0142(19920915)70:4+<1810::aid-cncr2820701624>3.0.co;2-3

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Article

Gene therapy of cancer through restoration of tumor-suppressor functions?

Cancer - 15 Sept 1992

Friedmann T

Abstract excerpt

The tools and concepts of gene therapy are being applied to the development of effective new treatments for human cancer. Most human cancers are associated with multiple interacting and cooperating mutations in protooncogenes and tumor suppressor genes. In several model systems, some features of...

Topics

Animals
Genes, Tumor Suppressor
Genetic Therapy
Humans
Lymphocytes, Tumor-Infiltrating
Lymphokines
Models, Biological
Mutation
Neoplasms
Phenotype
Proto-Oncogenes
Tumor Necrosis Factor-alpha

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