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Article

Effect of reactive site loop elongation on the inhibitory activity of C1-inhibitor.

Biochimica et biophysica acta - 1 Jun 2004

Bos Ineke G A, Lubbers Yvonne T P, Eldering Eric, Abrahams Jan Pieter, Hack C Erik

Abstract excerpt

The serine protease inhibitor C1-Inhibitor (C1-Inh) inhibits several complement- and contact-system proteases, which play an important role in inflammation. C1-Inh has a short reactive site loop (RSL) compared to other serpins. RSL length determines the inhibitory activity of serpins. We investigated the effect of RSL elongation on inhibitory activity of C1-Inh by insertion of one or two alanine residues in the...

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Identifiers

PMID: 15158721
DOI: 10.1016/j.bbapap.2004.02.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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