Article
[Mutation analysis of SHIP gene in acute leukemia].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Jul 2004
Luo Jian-min, Liu Ze-lin, Hao Hong-ling, Wang Fu-xu, Dong Zuo-ren, Ryuzo Ohno
Abstract excerpt
OBJECTIVE: The SH2 domain containing inositol 5'-phosphatase (SHIP) is predominately expressed in hematopoietic cells, and is a crucial negative regulator in the development of hematopoietic cells. This paper is to evaluate the role of the SHIP gene in human leukemogenesis. METHODS: Expression of SHIP gene in bone marrow and/or peripheral blood from 32 patients with acute myeloid leukemia (AML), 9 with acute...
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