Article
Association of the -514C-->T polymorphism in the hepatic lipase gene (LIPC) promoter with elevated fasting insulin concentrations, but not insulin resistance, in non-diabetic Germans.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 May 2004
Machicao F, Staiger H, Fritsche A, Guirguis A, Weisser M, Stumvoll M, Häring H-U
Abstract excerpt
Hepatic lipase hydrolyses triglycerides and phospholipids in all major classes of lipoproteins. The -514C-->T genetic variation in the hepatic lipase gene promoter was found to be associated with diminished lipase activity, dyslipidemia, and atherosclerosis. We investigated whether this polymorphism associates with hyperinsulinemia and insulin resistance in 535 normal glucose-tolerant Germans. Only in homozygous...
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