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Article

The -514 C/T polymorphism in the hepatic lipase gene promoter is associated with insulin sensitivity in a healthy young population.

Journal of molecular endocrinology - 1 Apr 2005

Gómez Purificación, Pérez-Jiménez Francisco, Marín Carmen, Moreno Juan Antonio, Gómez María José, Bellido Cecilia, Pérez-Martínez Pablo, Fuentes Francisco, Paniagua Juan Antonio, López-Miranda José

Abstract excerpt

Impaired insulin action has been associated with diabetes, dyslipidemia and atherosclerotic vascular disease. The expression of insulin resistance results from the interaction of environmental and genetic factors. Human hepatic lipase (HL) is a lipolytic enzyme that plays a role in the metabolism of several lipoproteins, while insulin up-regulates the activity of HL via insulin-responsive elements in the HL...

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Source

Identifiers

PMID: 15821100
DOI: 10.1677/jme.1.01627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The -514 C/T polymorphism in the hepatic lipase gene promoter is associated with insulin sensitivity in a healthy young population.PMID 15821100Read ↗

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Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men.Semantic proximity Read ↗

The apolipoprotein E gene promoter (-219G/T) polymorphism determines insulin sensitivity in response to dietary fat in healthy young adults.Semantic proximity Read ↗

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G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia.Semantic proximity Read ↗

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