Article
C-514T polymorphism in hepatic lipase gene promoter is associated with elevated triglyceride levels and decreasing insulin sensitivity in nondiabetic Japanese subjects.
International journal of molecular medicine - 1 Sept 2005
Yabu Yasuyoshi, Noma Katsura, Nakatani Kaname, Nishioka Junji, Suematsu Mina, Katsuki Akira, Hori Yasuko, Yano Yutaka, Sumida Yasuhiro, Wada Hideo, Nobori Tsutomu
Abstract excerpt
Hepatic lipase (HL) is synthesized in the liver and hydrolyses triglyceride and phospholipids. C-514T polymorphism in HL gene promoter was reported to associate with hepatic lipase activity and plasma lipid levels. We examined whether C-514T polymorphism affects glucose metabolism beyond its effect on plasma lipid levels in nondiabetic Japanese subjects. Gene frequencies of C/C homozygote, C/T heterozygote and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.