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Article

Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors.

PloS one - 1 Jan 2016

Mei Wenhan, Wang Kemin, Huang Jian, Zheng Xinmin

Abstract excerpt

Expression of wild-type protein tyrosine phosphatase (PTP) 1B may act either as a tumor suppressor by dysregulation of protein tyrosine kinases or a tumor promoter through Src dephosphorylation at Y527 in human breast cancer cells. To explore whether mutated PTP1B is involved in human carcinogenesis, we have sequenced PTP1B cDNAs from human tumors and found splice mutations in ~20% of colon and thyroid tumors....

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Source

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Identifiers

PMID: 27855221
DOI: 10.1371/journal.pone.0166538
PMCID: PMC5113951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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