Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic analysis of cytokine promoters in nonhuman primates: implications for Th1/Th2 profile characteristics and SIV disease pathogenesis.

Clinical & developmental immunology - 1 Mar 2004

Bostik Pavel, Watkins Melanie, Villinger Francois, Ansari Aftab A

Abstract excerpt

The shift from a predominant synthesis of prototype Th1 cytokines to Th2 or Th0 type of cytokines by antigen activated PBMC's from HIV infected humans and SIV infected disease susceptible rhesus macaques (RM) has been shown to be associated with disease progression. Paradoxically, antigen activated PBMC's from sooty mangabeys (SM), which are naturally infected with SIV and are disease resistant despite high viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Interferon-gamma
Share to Interleukin-10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-4

Share to Macaca mulatta

Share to Simian Acquired Immunodeficiency Syndrome

Share to Th1 Cells

Share to Th2 Cells

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 15154610
DOI: 10.1080/10446670410001670472
PMCID: PMC2275403

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic analysis of cytokine promoters in nonhuman primates: implications for Th1/Th2 profile characteristics and SIV disease pathogenesis.PMID 15154610Read ↗

Genetic variation at the TNF-alpha promoter and malaria susceptibility in rhesus (Macaca mulatta) and long-tailed (Macaca fascicularis) macaques.Semantic proximity Read ↗

Comparative sequence analysis of cytokine genes from human and nonhuman primatesSemantic proximity Read ↗

Primate TNF promoters reveal markers of phylogeny and evolution of innate immunity.Semantic proximity Read ↗

CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species: involvement of p300 and CREB at the proximal IL-2 promoter in IL-2 up-regulation.Semantic proximity Read ↗

Single nucleotide polymorphisms within the promoter region of the rhesus monkey tumor necrosis factor-alpha gene.Semantic proximity Read ↗

Genomic analysis of Th1-Th2 cytokine genes in an AIDS cohort: identification of IL4 and IL10 haplotypes associated with the disease progression.Semantic proximity Read ↗

Differential cytokine genotype frequencies among Canadian Aboriginal and Caucasian populations.Semantic proximity Read ↗

Inducible nitric oxide synthase (iNOS) regulatory region variation in non-human primates.Semantic proximity Read ↗

Difference in the level of interferon gamma mRNA transcripts on stimulation of cattle and buffalo mononuclear cells with foot and mouth disease virus-antigen: a possible role of sequence variation in promoter region.Semantic proximity Read ↗

Cytokine gene expression profiles during initiation, progression and resolution of periodontitisSemantic proximity Read ↗

MIP-1 alpha promoter polymorphism in humans and monkeys: identification of two polymorphic regions characterized by the insertion of unique sequences in monkeys.Semantic proximity Read ↗

A promoter polymorphism in the interferon alpha-2 gene is associated with the clinical presentation of hepatitis B.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.