Article
CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species: involvement of p300 and CREB at the proximal IL-2 promoter in IL-2 up-regulation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2007
Bostik Pavel, Noble Erika S, Stephenson Susan T, Villinger Francois, Ansari Aftab A
Abstract excerpt
IL-2 is an important cytokine required for the physiological function of CD4(+) T cells. Immunological unresponsiveness-anergy- of CD4(+) T cells is characterized by the inability of these cells to synthesize IL-2. Both progressive HIV infection leading to AIDS in humans and SIV infection in rhes...
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