Article
A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men.
American journal of human genetics - 1 Jul 2004
Feng Yan, Niu Tianhua, Xing Houxun, Xu Xin, Chen Changzhong, Peng Shaojie, Wang Lihua, Laird Nan, Xu Xiping
Abstract excerpt
Nicotine is the major addictive substance in cigarettes, and genes involved in sensing nicotine are logical candidates for vulnerability to nicotine addiction. We studied six single-nucleotide polymorphisms (SNPs) in the CHRNA4 gene and four SNPs in the CHRNB2 gene with respect to nicotine dependence in a collection of 901 subjects (815 siblings and 86 parents) from 222 nuclear families with multiple...
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