Article
Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene.
PloS one - 1 Jan 2014
Okada Yukinori, Diogo Dorothee, Greenberg Jeffrey D, Mouassess Faten, Achkar Walid A L, Fulton Robert S, Denny Joshua C, Gupta Namrata, Mirel Daniel, Gabriel Stacy, Li Gang, Kremer Joel M, Pappas Dimitrios A, Carroll Robert J, Eyler Anne E, Trynka Gosia, Stahl Eli A, Cui Jing, Saxena Richa, Coenen Marieke J H, Guchelaar Henk-Jan, Huizinga Tom W J, Dieudé Philippe, Mariette Xavier, Barton Anne, Canhão Helena, Fonseca João E, de Vries Niek, Tak Paul P, Moreland Larry W, Bridges S Louis, Miceli-Richard Corinne, Choi Hyon K, Kamatani Yoichiro, Galan Pilar, Lathrop Mark, Raj Towfique, De Jager Philip L, Raychaudhuri Soumya, Worthington Jane, Padyukov Leonid, Klareskog Lars, Siminovitch Katherine A, Gregersen Peter K, Mardis Elaine R, Arayssi Thurayya, Kazkaz Layla A, Plenge Robert M
Abstract excerpt
Integrating genetic data from families with highly penetrant forms of disease together with genetic data from outbred populations represents a promising strategy to uncover the complete frequency spectrum of risk alleles for complex traits such as rheumatoid arthritis (RA). Here, we demonstrate that rare, low-frequency and common alleles at one gene locus, phospholipase B1 (PLB1), might contribute to risk of RA...
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