Article
Regulation of inhibitory protein-kappaB and monocyte chemoattractant protein-1 by angiotensin II type 2 receptor-activated Src homology protein tyrosine phosphatase-1 in fetal vascular smooth muscle cells.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2004
Wu Lan, Iwai Masaru, Li Zhen, Shiuchi Tetsuya, Min Li-Juan, Cui Tai-Xing, Li Jian-Mei, Okumura Midori, Nahmias Clara, Horiuchi Masatsugu
Abstract excerpt
In the present study we examined the effects of angiotensin II (Ang II) type 2 (AT(2)) receptor stimulation on AT(1) receptor-mediated monocyte chemoattractant protein-1 (MCP-1) expression and the possible mechanisms of AT(2) receptor-mediated signaling in cultured rat fetal vascular smooth muscle cells, which express both AT(1) and AT(2) receptors. Ang II stimulation induced MCP-1 mRNA expression as well as an...
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