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Article

Selection of functional mutations in the U5-IR stem and loop regions of the Rous sarcoma virus genome.

BMC biology - 20 May 2004

Johnson Michael, Morris Shannon, Chen Aiping, Stavnezer Ed, Leis Jonathan

Abstract excerpt

BACKGROUND: The 5' end of the Rous sarcoma virus (RSV) RNA around the primer-binding site forms a series of RNA secondary stem/loop structures (U5-IR stem, TpsiC interaction region, U5-leader stem) that are required for efficient initiation of reverse transcription. The U5-IR stem and loop also encode the U5 integrase (IN) recognition sequence at the level of DNA such that this region has overlapping biological...

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Identifiers

PMID: 15153244
DOI: 10.1186/1741-7007-2-8
PMCID: PMC428589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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