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Article

In vivo selection of Rous sarcoma virus mutants with randomized sequences in the packaging signal.

Journal of virology - 1 Oct 1998

Doria-Rose N A, Vogt V M

Abstract excerpt

Retrovirus genomes contain a sequence at the 5' end which directs their packaging into virions. In Rous sarcoma virus, previous studies have identified important segments of the packaging signal, Psi, and support elements of a secondary-structure prediction. To further characterize this sequence, we used an in vivo selection strategy to test large collections of mutants. We generated pools of full-length viral...

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Identifiers

PMID: 9733847
DOI: 10.1128/JVI.72.10.8073-8082.1998
PMCID: PMC110144

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