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Article

Interaction between retroviral U5 RNA and the T psi C loop of the tRNA(Trp) primer is required for efficient initiation of reverse transcription.

Journal of virology - 1 Apr 1992

Aiyar A, Cobrinik D, Ge Z, Kung H J, Leis J

Abstract excerpt

The 5' end of avian sarcoma and leukosis virus RNA near the primer binding site forms two RNA secondary structures, U5-inverted repeat (U5-IR) and U5-leader stems, which are required for efficient initiation of reverse transcription. Lying between these two secondary structures is a 7-base sequence that can anneal to the T psi C loop of the tRNA(Trp) primer. Base substitutions in U5 RNA which disrupt this...

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Identifiers

PMID: 1548772
DOI: 10.1128/JVI.66.4.2464-2472.1992
PMCID: PMC289042

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Interaction between retroviral U5 RNA and the T psi C loop of the tRNA(Trp) primer is required for efficient initiation of reverse transcription.PMID 1548772Read ↗

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