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Article

Selection of Functional 5′ cis -Acting Elements Promoting Efficient Sindbis Virus Genome Replication

11 Dec 2003

Abstract excerpt

The 5' portion of the Sindbis virus (SIN) genome RNA is multifunctional. Besides initiating translation of the nonstructural polyprotein, RNA elements in the 5' 200 bases of the SIN genome RNA, or its complement at the 3' end of the negative-strand intermediate, play key roles in the synthesis of both negative- and positive-strand RNAs. We used here a combination of genetic and biochemical approaches to further...

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PMID: 14671088
DOI: 10.1128/jvi.78.1.61-75.2004

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