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Article

Genome coverage and sequence fidelity of phi29 polymerase-based multiple strand displacement whole genome amplification.

Nucleic acids research - 18 May 2004

Paez J Guillermo, Lin Ming, Beroukhim Rameen, Lee Jeffrey C, Zhao Xiaojun, Richter Daniel J, Gabriel Stacey, Herman Paula, Sasaki Hidefumi, Altshuler David, Li Cheng, Meyerson Matthew, Sellers William R

Abstract excerpt

Major efforts are underway to systematically define the somatic and germline genetic variations causally associated with disease. Genome-wide genetic analysis of actual clinical samples is, however, limited by the paucity of genomic DNA available. Here we have tested the fidelity and genome representation of phi29 polymerase-based genome amplification (phi29MDA) using direct sequencing and high density...

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Identifiers

PMID: 15150323
DOI: 10.1093/nar/gnh069
PMCID: PMC419624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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