Article
Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping.
BMC biotechnology - 27 Jul 2004
Pask Rebecca, Rance Helen E, Barratt Bryan J, Nutland Sarah, Smyth Deborah J, Sebastian Meera, Twells Rebecca C J, Smith Anne, Lam Alex C, Smink Luc J, Walker Neil M, Todd John A
Abstract excerpt
BACKGROUND: Sustainable DNA resources and reliable high-throughput genotyping methods are required for large-scale, long-term genetic association studies. In the genetic dissection of common disease it is now recognised that thousands of samples and hundreds of thousands of markers, mostly single nucleotide polymorphisms (SNPs), will have to be analysed. In order to achieve these aims, both an ability to boost...
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