Article
Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes.
Immunology - 1 Apr 2011
Korniejewska Anna, McKnight Andrew J, Johnson Zoë, Watson Malcolm L, Ward Stephen G
Abstract excerpt
The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 are involved in variety of inflammatory disorders including multiple sclerosis, rheumatoid arthritis, psoriasis and sarcoidosis. Two alternatively spliced variants of the human CXCR3-A receptor have been described, termed CXCR3-B and CXCR3-alt. Human CXCR3-B binds CXCL9, CXCL10, CXCL11 as well as an additional ligand CXCL4. In contrast,...
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