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Article

Fission yeast Skp1 is required for spindle morphology and nuclear membrane segregation at anaphase.

FEBS letters - 21 May 2004

Lehmann Anna, Toda Takashi

Abstract excerpt

Skp1 is a core component of the Skp1-Cullin-1-F-box ubiquitin ligase. Here, we show a novel role for fission yeast Skp1 in mitotic progression. Temperature-sensitive skp1-A7 mutants enter mitosis, but fail to execute anaphase. Time-lapse imaging shows that spindles in this mutant form intranuclear arch-like structures, which eventually collapse abruptly. The two spindle poles are also seen to move backward to the...

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Identifiers

PMID: 15147872
DOI: 10.1016/j.febslet.2004.04.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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