Article
Pregnancy-associated plasma protein-A (PAPP-A) expression and insulin-like growth factor binding protein-4 protease activity in normal and malignant ovarian surface epithelial cells.
International journal of cancer - 10 Jul 2004
Kalli Kimberly R, Chen Bing-Kun, Bale Laurie K, Gernand Erica, Overgaard Michael T, Oxvig Claus, Cliby William A, Conover Cheryl A
Abstract excerpt
Pregnancy-Associated Plasma Protein-A (PAPP-A) proteolyses insulin-like growth factor binding protein-4 (IGFBP-4), thereby regulating local IGF availability. Reduced PAPP-A mRNA expression has been reported in ovarian cancer specimens compared to normal ovarian surface epithelial cells (OSE). To characterize PAPP-A expression and proteolytic activity in OSE, we developed a lifespan-extended human cell model using...
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