Article
Differentiation and growth potential of human ovarian surface epithelial cells expressing temperature-sensitive SV40 T antigen.
In vitro cellular & developmental biology. Animal - 1 Sept 2001
Leung E H, Leung P C, Auersperg N
Abstract excerpt
The epithelial ovarian carcinomas arise in the ovarian surface epithelium (OSE) which is the mesothelial covering of the ovary. Studies of human USE have been hampered by the small amounts and limited lifespan of this epithelium in culture. OSE cells expressing SV40 large T antigen (Tag) or the HPV genes E6 and E7 have increased growth potentials but lack some of the normal characteristics of OSE. In this study,...
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