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Article

Differential contribution of IL-1Ra isoforms to allele-specific IL-1Ra mRNA accumulation.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Apr 2004

Redlitz Karen H, Yamshchikov Vladimir F, Cominelli Fabio

Abstract excerpt

The interleukin-1 (IL-1) receptor antagonist (IL-1Ra) gene produces two isoforms of IL-1Ra, intracellular (icIL-1Ra) and secreted (sIL-1Ra). Distinct promoter regions control synthesis of each isoform. Five alleles of this gene, defined by sIL-1Ra intron 2 polymorphism, have been described. Although differences in IL-1Ra protein production have been demonstrated in various tissues and cells obtained from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15144571
DOI: 10.1089/107999004323034123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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