Article
Novel interleukin-1 receptor antagonist exon polymorphisms and their use in allele-specific mRNA assessment.
Human genetics - 1 Jun 1996
Clay F E, Tarlow J K, Cork M J, Cox A, Nicklin M J, Duff G W
Abstract excerpt
A variable number of tandem repeats (VNTR) polymorphism has been described in intron 2 of the interleukin-1 receptor antagonist gene. Allele 2 of this polymorphism is associated with many chronic inflammatory diseases. Using direct sequencing of polymerase chain reaction products from individuals of known genotype for the VNTR, we have identified four single base change polymorphisms in exons 1ic and 2 and one...
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