Article
Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 May 2004
Jongepier H, Boezen H M, Dijkstra A, Howard T D, Vonk J M, Koppelman G H, Zheng S L, Meyers D A, Bleecker E R, Postma D S
Abstract excerpt
BACKGROUND: Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper-responsiveness due to airway inflammation and remodelling. The ADAM33 gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling. OBJECTIVE: To investigate whether polymorphisms of the ADAM33 gene are associated with...
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