Article
A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population.
American journal of respiratory and critical care medicine - 1 Aug 2005
van Diemen Cleo C, Postma Dirkje S, Vonk Judith M, Bruinenberg Marcel, Schouten Jan P, Boezen H Marike
Abstract excerpt
RATIONALE: A disintegrin and metalloprotease 33 (ADAM33) has been identified as a susceptibility gene for asthma and single nucleotide polymorphisms (SNPs) in this gene have been associated with excessive decline of lung function in individuals with asthma. OBJECTIVES: To assess whether SNPs in ADAM33 are associated with accelerated lung function loss in the general population and with chronic obstructive...
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