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Article

Contribution of ADAM33 polymorphisms to the population risk of asthma

24 Mar 2005

Abstract excerpt

BACKGROUND: ADAM 33 is the first gene identified as a candidate for asthma by positional cloning techniques, with association studies reaching impressive statistical significance. It has a postulated role in myogenesis, airway modelling, and signalling via protein shedding. Concerns over the methodology of the initial study have led to several attempts at replication, with inconsistent results. METHOD: To clarify...

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PMID: 15790980
DOI: 10.1136/thx.2004.027227

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