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Article

The dynamics of germinal centre selection as measured by graph-theoretical analysis of mutational lineage trees.

Developmental immunology - 1 Dec 2002

Dunn-Walters Deborah K, Belelovsky Alex, Edelman Hanna, Banerjee Monica, Mehr Ramit

Abstract excerpt

We have developed a rigorous graph-theoretical algorithm for quantifying the shape properties of mutational lineage trees. We show that information about the dynamics of hypermutation and antigen-driven clonal selection during the humoral immune response is contained in the shape of mutational lineage trees deduced from the responding clones. Age and tissue related differences in the selection process can be...

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Identifiers

PMID: 15144020
DOI: 10.1080/10446670310001593541
PMCID: PMC2276115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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